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Observational studies suggest that, similar to atypical antipsychotic drugs, treatment with conventional antipsychotic drugs may increase mortality.

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In spite of the relatively high rates of adverse effects associated with these drugs, some evidence, including higher dropout rates in placebo arms compared to treatment arms in randomized clinical trials, suggest that most patients who discontinue treatment do so because of suboptimal efficacy.

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Olanzapine Versus Lithium in the Maintenance Treatment of Bipolar Disorder: A 12-Month, Randomized, Double-Blind, Controlled Clinical Trial".

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Not licensed for use in the US.

If an overdose occurs, call your doctor or 911.

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What should I tell my doctor before taking ZYPREXA RELPREVV?

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Doses above 300 mg have not been studied.

Use of sodium oxybate with alcohol or sedative hypnotics is contraindicated.

Why is it so difficult to stop psychiatric drug treatment?

Zyprexa side effects Hypercholesterolemia - Too much cholesterol in the blood cells.

All patients on antidepressant therapy should be monitored and observed closely for clinical worsening, suicidality, or unusual changes in behavior.

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Mild risk of causing extrapyramidal symptoms (EPS): movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.

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It should not be used for treatment or management of psychotic symptoms caused by dementia.

For patients who have known or suspected abnormal hepatic function prior to starting ZYPREXA, standard clinical assessment including measurement of transaminase levels is recommended.

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ZYPREXA for injection in agitated patients with schizophrenia or bipolar mania.

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Not all patients gain weight on it, but those who are likely to experience this side effect usually declare themselves in the early weeks of treatment by showing an astonishing rate of weight gain.

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The risk for this sequence of hypotension, bradycardia, and sinus pause may be greater in nonpsychiatric patients compared to psychiatric patients who are possibly more adapted to certain effects of psychotropic drugs.

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Zyprexa side effects Asthenia - A physically weak condition.

Antipsychotics are only weakly recommended for Tourette syndrome, because although they are effective, side effects are common.

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Efficacy of olanzapine in combination with valproate or lithium in the treatment of mania in patients partially nonresponsive to valproate or lithium monotherapy.

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ZYPREXA RELPREVV is a long-acting form of olanzapine and is intended for deep intramuscular gluteal injection only.

In 3 of these patients, liver enzymes reverted to the normal range despite continued treatment, and in 5 cases enzymes values decreased, but were still above the normal range at the end of therapy.

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Children (10 to 17 years old) are also more likely to gain weight and to gain more weight than adults when Zyprexa is used in combination with fluoxetine.

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Despite the side effects and horrible impact on overall quality of life, for people with bad symptoms who cannot stand EPS symptoms and akathisia, this drug is a good option.

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Three normal volunteers in phase 1 studies with intramuscular ZYPREXA experienced hypotension, bradycardia, and sinus pauses of up to 6 seconds that spontaneously resolved (in 2 cases the events occurred on intramuscular olanzapine, and in 1 case, on oral ZYPREXA).

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Our studies indicate that lipocentric mechanisms or altered intermediary metabolism could underlie FFA lowering hyperglycemia (Randle cycle) as well as some of the other side effects of atypical antipsychotics, thereby suggesting strategies for alleviating them.

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For bipolar disorder, olanzapine can be used alone or in combination with other drugs.

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Talk with your doctor about these risks before you start your dose to determine if it is safe to use.

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Because of this risk, ZYPREXA RELPREVV is available only through a restricted distribution program called ZYPREXA RELPREVV Patient Care Program and requires prescriber, healthcare facility, patient, and pharmacy enrollment.

Question: Can Valium Interact with Zyprexa and Depakene?

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